Clinical Miedzo

Chinangwa: Chinangwa chechidzidzo ichi ndechekuongorora pharmacokinetic uye pharmacodynamic (PK-PD) profiles ye lispro inotungamirirwa neQS-M isina-jet jet injector muzvidzidzo zveChinese.

Tsvagiridzo yedhizaini uye nzira: A randomized, kaviri-mapofu, kaviri-dummy, cross-over kudzidza yakaitwa.Vazvipiri vane utano gumi nevasere vakapinzwa basa.Lispro (0.2 mauniti / kg) yaishandiswa neQS-M isina-jet jet injector kana nepeni yakajairika.Maawa manomwe euglycemic clamp miedzo yakaitwa.Vazvipiri gumi nevasere (varume vapfumbamwe nevakadzi vapfumbamwe) vakapinzwa muchidzidzo ichi.Maitiro ekubatanidzwa aiva: vasingasvuti vane makore 18-40, vane body mass index (BMI) ye17-24 kg / m2;zvidzidzo zvine zvakajairika biochemical test, blood pressure, uye electrocardiograph;vanhu vakasaina chibvumirano chavanoziva.Nzira yekuregererwa yaiva: zvidzidzo ne insulin allergies kana imwe nhoroondo yehutano;vanhu vane zvirwere zvisingaperi zvakadai seshuga, zvirwere zvemwoyo, chiropa kana chirwere cheitsvo.Zvidzidzo zvainwa doro zvaisabatanidzwawo.Chidzidzo ichi chakabvumidzwa neEthics Committee yeFirst Affiliated Hospital yeChongqing Medical University.

Migumisiro: Nzvimbo yakakura pasi pe curve (AUCs) ye insulin concentration uye glucose infusion rate (GIR) munguva yekutanga 20 maminetsi mushure mejojo ​​ye lispro nejet injector kana ichienzaniswa ne insulin pen yakaonekwa (24.91 ± 15.25 vs. 12.52 ± 7.60 mg kg−1, P <0.001 yeAUCGIR,0–20 min; 0.36 ± 0.24 vs. 0.10 ± 0.04 U min L−1, P <0.001 yeAUCINS, 0–20 min).Jekiseni isina tsono yakaratidza nguva shoma kuti isvike yakanyanya insulin concentration (37.78 ± 11.14 vs. 80.56 ± 37.18 min, P <0.001) uye GIR (73.24 ± 29.89 vs. 116.18 ± 51.89 min, P = 0.6).Pakanga pasina misiyano mune yakazara insulin kuratidzwa uye hypoglycemic mhedzisiro pakati pemidziyo miviri.Mhedziso: Lispro inotungamirwa neQS-M isina-tsono jekiseni inoguma nekutanga uye yakakwirira insulin kuratidzwa pane yakajairika peni, uye yakakura yekutanga-kudzikisa glucose ine simba rakafanana.